Alpha Ketoglutarate (AKG) Supplements

In a landmark longevity study†, conducted by researchers at the prestigious Buck Institute for Research on Aging, Rejuvant’s LifeAKG (proprietary Alpha-Ketoglutarate (AKG supplement) was shown to:

  • Reduce Frailty by 46%
  • Increase Lifespan by 12%
  • Improvement Healthspan by 41%
  • Decrease Morbidity Stage by 50%

Take Rejuvant LifeTabs Today For A More Youthful Tomorrow

The Importance of AKG as we age

Our bodies naturally produce high levels of Alpha-Ketoglutarate (AKG) until age 40. But after age 40, levels of AKG drastically drop. We all need AKG to live a healthy, longer life. And we can’t get enough of it by eating food.

That’s why we need Rejuvant LifeTabs

Rejuvant LifeTabs is a once-daily dietary supplement, containing the patent-pending ingredient, LifeAKG™. LifeAKG is a proprietary, sustained-release form of AKG which is safe, free of unwanted drug side effects, and scientifically shown to extend life.

Just as importantly, the gold-standard study showed LifeAKG increased the healthspan, the healthiest years of life, by 41%, reducing 32 different signs of age-related frailty.

Rejuvant LifeTabs™ Contains A Well-researched, Safe Ingredient Called LifeAKG™

LifeAKG, a highly pure, patent-pending, and sustained-release form of Calcium Alpha-Ketoglutarate (Ca-AKG), has been shown to be an anti-aging ingredient powerhouse. Only LifeAKG has been shown to increase both lifespan and healthspan (the healthiest years of living) in the gold standard model for longevity research.†

  • Generates cellular energy to maintain vitality
  • Reduces age-related inflammation
  • Detoxifies ammonia levels in cells
  • Maintains DNA structure, rewinding biological age

The Culmination of Twenty Years of Longevity and Anti-Aging Research

When researchers at the world-renowned Buck Institute for Research on Aging began testing the LifeAKG found in Rejuvant LifeTabs and investigated its potential benefits on the aging process, what they discovered was remarkable.

They found that LifeAKG™ demonstrated an ability to modulate both the known and newly discovered pathways associated with aging. In short, transforming the way we age for the better.

What to Expect From Our Alpha-Ketoglutarate (AKG) Supplement

Ammonia Detoxification

We’ve all heard about the benefits of high protein, so we usually think having more protein is a good thing. 

But when the body breaks down protein, it forms trace amounts of ammonia

Yes, ammonia, which starts to build up over your lifetime in your brain, muscles, liver and kidneys.

The good news is that, thanks to AKG, your body is able to deal with this toxin quickly and efficiently. 

But unfortunately, as we age our levels of AKG drop, as does our body’s ability to neutralize this harmful substance. 

This is why the key ingredient in Rejuvant is called LifeAKG.

DNA Integrity – Methylation Increases as We Age

DNA is key to vitality by making new cells in our body and determining how those cells will ultimately function. 

With age comes a process called methylation. Think of this as a kind of “rust” that coats the outer portions of your DNA. 

Methyl groups are chemical tags, that in effect block our DNA from doing its job when it comes to making ideal copies of itself, activating and deactivating certain genes.

The more methylation, the more difficult it is for DNA to make a perfect, readable copy of itself. 

This increases the chance of passing on flawed genetic information, leading to poorly functioning cells, and contributing to aging itself.

In a healthy cellular maintenance process, AKG is involved in demethylation, by cleaning up and removing these DNA tags so that the correct genes continue to be expressed. 

With correct levels of AKG, our DNA maintains a more balanced methylation profile, assisting cells to function at optimal levels, similar to when we are younger.

Generating Cellular Energy for Now…and Later

ATP is the energy powerhouse found in all living cells. Here again, our old friend AKG found in LifeAKG, plays a major role in how much ATP is produced in your body for immediate power. 

As a part of the Krebs Cycle, cells are literally powered by this vital nutrient.

AKG also acts like an “on-off switch,” to save energy, especially when the body is under stress. 

Regulating ATP production is critically important, so that in later years when we need energy the most, we have plenty of it.

 

Select Studies Supporting LifeAKG

† Azar Asadi Shahmirzadi, et al. “Alpha-ketoglutarate, an endogenous metabolite, extends lifespan and compresses morbidity in aging mice.” doi: https://doi.org/10.1101/779157.

https://www.biorxiv.org/content/10.1101/779157v1 

Kjellman, Ulf W., et al. “Addition of α-ketoglutarate to blood cardioplegia improves cardioprotection.” The Annals of Thoracic Surgery 63.6 (1997): 1625-1633

Kjellman, Ulf, et al. “α-ketoglutarate for myocardial protection in heart surgery.” The Lancet 345.8949 (1995): 552-553

Jeppsson, Anders, et al. “Renal effects of α-ketoglutarate early after coronary operations.” The Annals of Thoracic Surgery 65.3 (1998): 684-690.

Zimmermann, E., S. Wassmer, and V. Steudle. “Long-term treatment with calcium-alpha-ketoglutarate corrects secondary hyperparathyroidism.” Mineral and Electrolyte Metabolism22.1-3 (1996): 196-199.

Riedel, E., et al. “Calcium alpha-ketoglutarate administration to malnourished hemodialysis patients improves plasma arginine concentrations.” Mineral and Electrolyte Metabolism22.1-3 (1996): 119-122.

Riedel, Eberhard, Michael Nündel, and Hannelore Hampl. “α-Ketoglutarate application in hemodialysis patients improves amino acid metabolism.” Nephron 74.2 (1996): 261-265.

Birck, Rainer, et al. “Calcium ketoglutarate versus calcium acetate for treatment of hyperphosphataemia in patients on maintenance haemodialysis: a cross-over study.” Nephrology, Dialysis, Transplantation: Official Publication of the European Dialysis and Transplant Association-European Renal Association 14.6 (1999): 1475-1479.

Filip, et al. “Alpha-ketoglutarate decreases serum levels of C-terminal cross-linking telopeptide of type I collagen (CTX) in postmenopausal women with osteopenia: six-month study.” International Journal for Vitamin and Nutrition Research 77.2 (2007): 89-97.

Wernerman, J., F. Hammarqvist, and E. Vinnars. “α-Ketoglutarate and postoperative muscle catabolism.” The Lancet 335.8691 (1990): 701-703.

Wirén, Mikael, Johan Permert, and J. örgen Larsson. “α-ketoglutarate–supplemented enteral nutrition: effects on postoperative nitrogen balance and muscle catabolism.” Nutrition 18.9 (2002): 725-728.

Mittal, Gaurav, et al. “Radiolabeling and dose fixation study of oral alpha-ketoglutarate as a cyanide antidote in healthy human volunteers.” Clinical Toxicology 48.6 (2010): 509-515.

Bro, Susanne, et al. “Randomized crossover study comparing the phosphate-binding efficacy of calcium ketoglutarate versus calcium carbonate in patients on chronic hemodialysis.” American Journal of Kidney Diseases 31.2 (1998): 257-262.

Blomqvist, Britt I., et al. “Glutamine and α-ketoglutarate prevent the decrease in muscle free glutamine concentration and influence protein synthesis after total hip replacement.” Metabolism 44.9 (1995): 1215-1222.

Hammarqvist, F., J. Wernerman, and E. Vinnars. “Alpha-ketoglutarate preserves protein synthesis and free glutamine in skeletal muscle after surgery.” Surgery 109.1 (1991): 28-36.

† Based on mammalian studies

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